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CAPE; Caffeic Acid Phenethyl Ester, Phenethyl caffeate CAS#104594-70-9, 1kg/bag
Introduction
· Latin Name:CAPE; Caffeic Acid Phenethyl Ester
Phenethyl caffeate/104594-70-9
· Test Method:HPLC
Propolis is a resinous substance that bees collect from tree buds or other botanical sources. It is used as a sealant for unwanted open spaces in the hive. Propolis is used for small gaps (approximately 6.35 millimeters (0.3 in) or less), while larger spaces are usually filled with beeswax. Its color varies from green to reddish brown depending of its botanical source; the most common being dark brown.
For centuries, beekeepers assumed that bees sealed the beehive with propolis to protect the colony from the elements, Such as rain and cold winter drafts. However, 20th century research has revealed that bees not only survive, but also thrive, with increased ventilation during the winter months throughout most temperate regions of the world.
Function
Caffeicacidhasbeenshowntoinhibitcarcinogenesis,althoughotherexperimentsshowpossiblecarcinogenic
effects.Itisalsoknownasanantioxidantinvitroandalsoinvivo.
Caffeicacidalsoshowsimmunomodulatoryandantiinflammtoryactivity.Caffeicacidoutperformedtheotherantioxidants,reducingaflatoxinproductionbymorethan95percent.ThestudiesarethefirsttoshowthatoxidativestressthatwouldotherwisetriggerorenhanceAspergillusflavusaflatoxinproductioncanbestymiedbycaffeicacid.Thisopensthedoortousingnaturalantifungicidemethodsbysupplementingtreeswithantioxidants.AnotherstudyalsoshowedthatCAPEsuppressesacuteimmuneandinflammatoryresponsesandholdspromisefortherapeuticusestoreduceinflammation.
Application
Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have
1. Anti-mitogenic,
2. Anti-carcinogenic,
3. Anti-inflammatory,
4. Anti-cancer
5. Immunomodulatory properties.
A potent and specific inhibitor of the activation of nuclear transcription factor NF-KB. It is also exhibits inhibitory activity against HIV-1 integrase with IC50 of 7uM.
Specification
|
Item |
Specification |
Result |
|
Appearance |
Whitetolightyellowcrystallinepowder |
Complies |
|
Relatedsubstance(HPLC) |
Totalimpurity≤0.5% Singleimpurity≤0.1% |
0.2% 0.06% |
|
Odor |
Characteristic |
Complies |
|
Assay |
99% |
99.8% |
|
Sieveanalysis |
100%pass80mesh |
Complies |
|
LossonDrying ResidueonIgnition |
≤1.0% ≤1.0% |
0.12% 0.09% |
|
HeavyMetal |
<10ppm |
Complies |
|
As |
<0.1ppm |
0.05ppm |
|
Pb |
<0.1ppm |
0.05ppm |
|
Cd |
<0.1ppm |
0.05ppm |
|
ResidualSolvents |
<100ppm |
Complies |
|
ResidualPesticide |
Negative |
Complies |
|
Microbiology |
|
|
|
TotalPlateCount |
<1000cfu/g |
Complies |
|
Yeast&Mold |
<100cfu/g |
Complies |
|
E.Coli |
Negative |
Complies |
|
Salmonella |
Negative |
Complies |
|
Reference 1.Hydroxylated aromatic inhibitors of HIV-1 integrase: T.R. Burke Jr., et al.; J. Med. Chem. 38, 4171 (1995) Abstract
|
||
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